Biologic response modifiers: Indications, implications, and insights
نویسندگان
چکیده
منابع مشابه
Biologic Response Modifiers
Despite remarkable advances in therapy, rheumatoid arthritis (RA) still results in significant morbidity, mortality, and disability [1]. In addition to symmetrical joint swelling of the feet and hands, large joints such as the shoulders, hips, knees, and cervical spine can be affected. RA also may affect the pulmonary, cardiovascular, and ocular systems. Rheumatoid factor is present in up to 80...
متن کاملBiologic response modifiers in gynecologic malignancies.
Biological therapy is currently being investigated in the treatment of a number of malignancies. The hypothesis for the use of this therapeutic modality involves an attempt to stimulate an already existent but perhaps suboptimal immune response to foreign protein, including tumor. Immunologic therapy appears to work best against small-volume disease, as indicated from animal studies. This condi...
متن کاملResponse of tumors to biologic modifiers and chemotherapeutic agents.
The use of the FANFT model has facilitated clinical trials which are now beginning to have an impact on the therapy of human bladder tumors. We studied C. parvum and Glucan immunotherapy of FANFT tumors, and demonstrated the enhancement of tumor growth following Glucan administration. Weekly injections of cyclophosphamide (CY) retarded tumor growth and increased survival. Combining C. parvum or...
متن کاملOverview of biologic response modifiers in infectious disease.
The conventional treatment of infectious agents is increasingly encountering antimicrobial resistance. This resistance has led to an intense search for novel treatment modalities for infectious diseases. Elucidation of the mechanisms underlying the inhibitory activity of chemokines has been instrumental in the rational design of anti-human immunodeficiency virus chemokine drugs. The immune-base...
متن کاملThe Right Ventricle: Biologic Insights and Response to Disease
Despite ample evidence that right ventricular function is a critical determinant of the clinical response to a spectrum of cardiovascular diseases, there has been only a limited analysis of the unique and distinguishing physiologic properties of the RV under normal circumstances and in response to pathologic insults. This review highlights some of these features and underscores the fact that ra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Allergy and Clinical Immunology
سال: 2017
ISSN: 0091-6749
DOI: 10.1016/j.jaci.2017.02.013